Lewis Drug

Lewis Drug is a privately owned pharmacy and retail chain based in Sioux Falls, South Dakota, with a longstanding presence across South Dakota, Minnesota, and Iowa. The company was established in 1942 by Jesse Lewis and George Fredrickson, who opened the first store in downtown Sioux Falls. This location was notable for being the first self-service drugstore in South Dakota, setting a precedent for retail innovation in the region.

As of November 2025, Lewis Drug operates 58 stores, reflecting steady growth from its single-store origins. Over the past five years, the company has focused on expanding its footprint through both new store openings and the remodeling of existing locations. Recent growth has concentrated on underserved communities, particularly in its core states, and has included a mix of ground-up developments and strategic acquisitions. Lewis Drug often prioritizes sites near healthcare providers and in areas experiencing residential expansion, which has helped the brand maintain relevance in evolving markets.

The company’s store formats range from full-service pharmacies to neighborhood convenience stores and larger locations that combine pharmacy services with grocery and general merchandise. This flexibility allows Lewis Drug to serve a variety of community needs and adapt to different retail environments. A significant milestone in the company’s history was the opening of its flagship Sioux Falls store in 2000, which introduced a broader product assortment and larger format to the region.

Today, Lewis Drug remains independent and family-operated, with Mark Griffin serving as President and CEO. The brand is recognized for its strong local reputation and deep community connections. Its continued expansion and adaptable store formats have positioned Lewis Drug as a reliable anchor and preferred tenant in both new and redeveloped retail projects throughout the Upper Midwest.