Medicine Shoppe

Medicine Shoppe is a pharmacy franchise that has been part of communities across the United States since its founding in 1968. The company began in St. Louis, Missouri, when pharmacist Michael Busch opened the first location with a focus on personalized service and independent ownership. This approach resonated with local pharmacists, and the brand expanded rapidly through the 1970s and 1980s. By the late 1990s, Medicine Shoppe had grown to over 1,000 locations, making it a well-known name in both urban and rural settings.

A significant milestone in the company’s history came in 1995, when Cardinal Health acquired Medicine Shoppe International. This move brought the pharmacy network under the umbrella of a major healthcare services provider, giving franchisees access to broader resources and supply chain support. Over the past five years, Medicine Shoppe has concentrated on maintaining a stable presence, with a measured approach to growth. The company’s footprint has shifted, and as of November 2025, there are approximately 250 independently owned and operated Medicine Shoppe pharmacies nationwide. Most of these stores are found in small towns and suburban areas, with a particular focus on the Midwest and South, as well as other communities that may be underserved by larger pharmacy chains.

Medicine Shoppe’s format is consistent and community-oriented, typically offering prescription services, immunizations, medication management, and a selection of over-the-counter health products. The franchise model means that each location is locally owned, which often translates to long-term tenant stability and deep ties to the surrounding neighborhood. While the overall store count has declined from its peak, the brand continues to open new locations selectively in markets where independent pharmacy services are in demand. Real estate contacts for new sites and renewals are generally handled by Cardinal Health, reflecting the company’s franchise structure and the parent organization’s role in supporting the network.

Medicine Shoppe’s established reputation, consistent store model, and ongoing relationship with Cardinal Health contribute to its credibility as a pharmacy tenant. The brand’s focus on measured expansion and support for franchisees positions it as a steady presence in healthcare retail, particularly in areas where personalized pharmacy care remains a valued community resource.